A new, decadally resolved record of the <sup>10</sup>Be peak at Pan Handle Covers 41 kyr from the EPICA Dome C ice core (Antarctica) is used to match it with the same peak in the GRIP ice core (Greenland).This permits a direct synchronisation of the climatic variations around this time period, independent of uncertainties related to the
(7aR)-1-[(2R,5S,E)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methylhexahydro-1H-inden-4(2H)-one
The chiral title compound, C19H32O2, contains a Whip [4.3.0]-bicyclic moiety in which the shared C—C bond presents a trans configuration and a side chain in which the C=C double bond shows an E conformation.The conformations of five- and six-membered rings are envelope (with the bridgehead atom bearing the methyl substituent as the flap) and
Misfolding of a Single Disulfide Bonded Globular Protein into a Low-Solubility Species Conformationally and Biophysically Distinct from the Native One
In practice and despite Anfinsen’s dogma, the refolding of recombinant multiple SS-bonded proteins is famously difficult because misfolded species with non-native SS-bonds appear upon the oxidization of their cysteine residues.On the other hand, single SS-bond proteins are thought to be simple to refold because their cysteines have only one S
Use of extraocular muscle flaps in the correction of orbital implant exposure.
PURPOSES: The study is to describe a new surgical technique for correcting large orbital implant exposure with extraocular muscle flaps and to propose a treatment CLEANSE MORE algorithm for orbital implant exposure.METHODS: In a retrospective study, seven patients with orbital implant exposure were treated with extraocular muscle flaps.All data wer